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KMID : 0363320110320020278
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Journal of Korean Oriental Internal Medicine
2011 Volume.32 No. 2 p.278 ~ p.287
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Effects of Sojongchobisunki-tang on Cisplatin-induced Rat Acute Renal Failure
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Yoon Gyeong-Min
Kang Suk-Bong
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Abstract
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Objectives: The object of this study was to observe the nephroprotective effects of Sojongchobisunki-tang (SCST), which has traditionally been used as Korean medicine for treating various renal diseases, on cisplatin-induced rat acute renal failure.
Methods: Three different dosages of SCST were orally administered once a day for 23 days before cisplatin treatment (5 mg/kg, single intraperitoneally administered) and 5 days after cisplatin treatment (once a day for 28 days). 6 groups, of 8 rats per group were used in the present study after 7 days of acclimatization. Changes of the body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes of the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg of which the effects on cisplatin-induced acute renal failures are already confirmed.
Results: Acute renal failure induced by cisplatin were induced by oxidative stress and related lipid peroxidation in the present study. However, these acute renal failures and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment at all three different dosages of SCST extracts.
Conclusions : This study suggests that SCST extracts showed favorable effects on the cisplatin-induced rat ARF.
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KEYWORD
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Sojongchobisunki-tang (xiaozhongdiaopishunqi-tang), acute renal failure, cisplatin, antioxidant effect
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